Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation.

International journal of cardiology - 9 Feb 2012

Cascales Almudena, Sánchez-Vega Beatriz, Navarro Noelia, Pastor-Quirante Francisco, Corral Javier, Vicente Vicente, de la Peña Francisco Ayala

Abstract excerpt

BACKGROUND: The involvement of iron in anthracycline cardiotoxicity is supported by extensive experimental data, and by the preventive efficacy of dexrazoxane, an iron chelator. However, no clinical evidence of anthracycline-induced cardiac iron accumulation is available and the influence of previous iron overload or of genetic factors in human-induced heart disease is largely unknown. Our aim was to test the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthracyclines
Share to Cadaver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to Membrane Proteins

Share to Myocardium

Source

Identifiers

PMID: 20974500
DOI: 10.1016/j.ijcard.2010.09.046

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation.PMID 20974500Read ↗

HFE Gene Variants' Impact on Anthracycline-Based Chemotherapy-Induced Subclinical Cardiotoxicity.Semantic proximity Read ↗

Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.Semantic proximity Read ↗

Genotyping the risk of anthracycline-induced cardiotoxicity.Semantic proximity Read ↗

Genetic susceptibility to anthracycline-related congestive heart failure in survivors of haematopoietic cell transplantation.Semantic proximity Read ↗

Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.Semantic proximity Read ↗

Hemochromatosis gene variants in patients with cardiomyopathy.Semantic proximity Read ↗

Hemochromatosis gene (HFE) mutations and cancer riskSemantic proximity Read ↗

Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer.Semantic proximity Read ↗

Association of HFE Gene Mutations With Serum Ferritin Level and Heart and Liver Iron Overload in Patients With Transfusion-dependent Beta-Thalassemia.Semantic proximity Read ↗

HFE H63D mutation frequency shows an increase in Turkish women with breast cancer.Semantic proximity Read ↗

On myocardial siderosis and left ventricular dysfunction in hemochromatosis.Semantic proximity Read ↗

HFE gene mutation is a risk factor for tissue iron accumulation in hemodialysis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.