Article
Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2004
Kallianpur Asha R, Hall Lynn D, Yadav Meeta, Christman Brian W, Dittus Robert S, Haines Jonathan L, Parl Fritz F, Summar Marshall L
Abstract excerpt
Individuals with the major hemochromatosis (HFE) allele C282Y and iron overload develop hepatocellular and some extrahepatic malignancies at increased rates. No association has been previously reported between the C282Y allele and breast cancer. We hypothesized that due to the pro-oxidant properties of iron, altered iron metabolism in C282Y carriers may promote breast carcinogenesis. Because 1 in 10 Caucasians of...
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