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Article

Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.

European journal of medicinal chemistry - 15 Mar 2020

Shen Dadong, Chen Wenxia, Zhu Jinlin, Wu Guofeng, Shen Runpu, Xi Meiyang, Sun Haopeng

Abstract excerpt

Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by PTPN11, regulates cell proliferation, differentiation, apoptosis and survival via releasing intramolecular autoinhibition and modulating various signaling pathways, such as mitogen-activated protein kinase (MAPK) pathway. Mutations and aberrant expression of SHP2 are implicated in human developmental disorders, leukemias and several...

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PMID: 32061959
DOI: 10.1016/j.ejmech.2020.112117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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