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Article

Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11).

BMC structural biology - 14 Mar 2014

Qiu Wei, Wang Xiaonan, Romanov Vladimir, Hutchinson Ashley, Lin Andrés, Ruzanov Maxim, Battaile Kevin P, Pai Emil F, Neel Benjamin G, Chirgadze Nickolay Y

Abstract excerpt

BACKGROUND: The ubiquitous non-receptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) plays a key role in RAS/ERK signaling downstream of most, if not all growth factors, cytokines and integrins, although its major substrates remain controversial. Mutations in PTPN11 lead to several distinct human diseases. Germ-line PTPN11 mutations cause about 50% of Noonan Syndrome (NS), which is among the most common...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen Bonding

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Source

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Identifiers

PMID: 24628801
DOI: 10.1186/1472-6807-14-10
PMCID: PMC4007598

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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