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Article

Genetics of pain perception, COMT and postoperative pain management in children.

Pharmacogenomics - 1 Feb 2014

Sadhasivam Senthilkumar, Chidambaran Vidya, Olbrecht Vanessa A, Esslinger Hope R, Zhang Kejian, Zhang Xue, Martin Lisa J

Abstract excerpt

BACKGROUND: Effective perioperative analgesia is lacking for children owing to interindividual variations and underdosing of opioids caused by fear of adverse effects. We investigated the role of COMT SNPs on postoperative pain management in children. METHODS: One hundred and forty nine children undergoing adenotonsillectomy were enrolled. The associations of four COMT SNPs (rs6269, rs4633, rs4818 and rs4680)...

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Source

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Identifiers

PMID: 24533707
DOI: 10.2217/pgs.13.248
PMCID: PMC4151110

Genes

COMT

Provenance

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