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Article

Effects of age and gender on the cytochrome P450 2D6 activity in a Korean population.

Journal of clinical pharmacy and therapeutics - 1 Dec 2021

Park Pil-Whan, Seo Yiel-Hea, Ahn Jeong-Yeal, Kim Kyoung-Ah, Park Ji-Young

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Age and gender have been reported to play a crucial role in modulating the disposition of pharmacological agents, and to influence the activities of cytochrome P450 (CYP) 2D6, a drug-metabolizing enzyme involved in the disposition of clinically used drugs. In the present study, the effects of age and gender on the CYP2D6 activity were evaluated using dextromethorphan as a probe drug...

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Identifiers

PMID: 34355409
DOI: 10.1111/jcpt.13507

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