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Human Sirtuin 2 inhibitors, Their Mechanisms and Binding Modes

1 Feb 2023

Abstract excerpt

The silent information regulator (sirtuin) is a family of enzymes involved in epigenetic processes with lysine deacetylase activity, having as substrates histones and other proteins. They participate in a wide range of cellular and pathologic processes, such as gene expression, cell division and motility, oxidative-induced stress management, metabolic control and carcinogenesis, among others, thus presenting as...

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PMID: 36892013
DOI: 10.4155/fmc-2022-0253

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