Article

Rare protein-disrupting variants in <i>NPY5R, DLGAP1</i> and <i>MAPK8IP3</i> segregate with OCD in two multiplex pedigrees

2026-04-22

Abstract excerpt

Obsessive compulsive disorder (OCD) is significantly heritable, but only a fraction of the contributory genetic variation has been identified, and the molecular etiology involved remains obscure. Identifying rare contributory variants of large effect would be an important milestone in helping to elucidate the mechanisms involved. Analysis of densely affected pedigrees is a potentially useful strategy to bypass the...

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Literature Corpus work: 7c61a448-6901-59a3-8d00-6b206a79eb6a
DOI: 10.64898/2026.04.21.26350600

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