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Article

HIV-1-Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, and Nef, but Depends on the Cellular Phenotype Status.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2016

Gomez Alejandro M, Ouellet Michel, Deshiere Alexandre, Breton Yann, Tremblay Michel J

Abstract excerpt

HIV-1 infection is characterized by persistent viral replication, chronic immune activation, and CD4(+) T cell depletion. Moreover, several immune dysfunctions are observed in cells that are not targeted by the virus, such as B cells. Some B cell abnormalities include hypergammaglobulinemia, nonspecific B cell activation, class switching, increased cell turnover, breakage of tolerance, and a loss of the capacity...

Read the complete abstract on PubMed

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Share to Toll-Like Receptors
Share to B-Cell Activating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Interferon Type I

Share to Macrophages

Share to nef Gene Products, Human Immunodeficiency Virus

Share to RNA, Small Interfering

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Source

Identifiers

PMID: 27022194
DOI: 10.4049/jimmunol.1501249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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