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Article

HIV-1 envelope–receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies

24 Oct 2013

Abstract excerpt

Myeloid cells residing in the CNS and lymphoid tissues are targets for productive HIV-1 replication, and their infection contributes to the pathological manifestations of HIV-1 infection. The Envs can adopt altered configurations to overcome entry restrictions in macrophages via a more efficient and/or altered mechanism of engagement with cellular receptors. This review highlights evidence supporting an important...

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PMID: 24158961
DOI: 10.1189/jlb.0713368

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