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Phenotypic Correlates of HIV-1 Macrophage Tropism

3 Sept 2015

Abstract excerpt

UNLABELLED: HIV-1 is typically CCR5 using (R5) and T cell tropic (T-tropic), targeting memory CD4(+) T cells throughout acute and chronic infections. However, viruses can expand into alternative cells types. Macrophage-tropic (M-tropic) HIV-1 variants have evolved to infect macrophages, which have only low levels of surface CD4. Most M-tropic variants have been isolated from the central nervous system during...

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PMID: 26339058
DOI: 10.1128/jvi.00946-15

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