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Article

Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities.

Journal of virology - 1 Feb 2014

Joseph Sarah B, Arrildt Kathryn T, Swanstrom Adrienne E, Schnell Gretja, Lee Benhur, Hoxie James A, Swanstrom Ronald

Abstract excerpt

Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte-derived macrophages (MDMs) in vitro, and MDMs vary in their ability to support HIV-1 entry. To overcome these limitations, we identified consistent differences in entry phenotypes between five paired blood-derived, T cell-tropic HIV-1...

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Topics

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Share to CD4 Antigens
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to Flow Cytometry

Share to HEK293 Cells

Share to Luciferases

Share to Macrophages

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 24307580
DOI: 10.1128/JVI.02477-13
PMCID: PMC3911544

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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