Article
High expression levels of BLyS/BAFF by blood dendritic cells and granulocytes are associated with B-cell dysregulation in SIV-infected rhesus macaques.
PloS one - 1 Jan 2015
Poudrier Johanne, Soulas Caroline, Chagnon-Choquet Josiane, Burdo Tricia, Autissier Patrick, Oskar Kathryn, Williams Kenneth C, Roger Michel
Abstract excerpt
Dendritic cells (DCs) modulate B-cell survival and differentiation, mainly through production of growth factors such as B lymphocyte stimulator (BLyS/BAFF). In recent longitudinal studies involving HIV-1-infected individuals with different rates of disease progression, we have shown that DCs were altered in number and phenotype in the context of HIV-1 disease progression and B-cell dysregulations were associated...
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