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Article

Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors

28 Mar 2016

Abstract excerpt

PURPOSE: Inhibition of AKT is a key target area for personalized cancer medicine. However, predictive markers of response to AKT inhibitors are lacking. Correspondingly, the AKT-dependent chain of command for tumor growth, which will mediate AKT-dependent therapeutic responses, remains unclear. EXPERIMENTAL DESIGN: Proteomic profiling was utilized to identify nodal hubs of the Trop-2 cancer growth-driving...

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PMID: 27022065
DOI: 10.1158/1078-0432.ccr-15-1701

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