Article

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

2022-10-11

Abstract excerpt

Over 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, there remains scope to improve upon the therapeutic window of the current generation of AKT inhibitors. Here we report the development of a second-generation AKT degrader, INY-05-040, which outperformed catalytic AKT inhibition with respect to cellular suppression of AKT-driven phenotypes in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e3a9771-d5f4-521d-8d1c-a43b82dee12e
DOI: 10.1101/2022.10.11.511726

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradationDOI 10.1101/2022.10.11.511726Read

Pan-cancer proteogenomic investigations identify post-transcriptional kinase targetsSemantic proximity Read

Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapiesSemantic proximity Read

Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast CancerSemantic proximity Read

Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patientsSemantic proximity Read

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genesSemantic proximity Read

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistanceSemantic proximity Read

The Akt pathway in oncology therapy and beyond (Review)Semantic proximity Read

HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B.Semantic proximity Read

Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes.Semantic proximity Read

(Phospho)proteomic Profiling Reveals Mutation-Specific Adaptive Signaling to PI3Kα Inhibition in PIK3CA Mutant Breast Epithelial Cells.Semantic proximity Read

Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT InhibitorsSemantic proximity Read

Targeting a cell state common to triple‐negative breast cancersSemantic proximity Read