Article
Upregulation of Trop-2 quantitatively stimulates human cancer growth.
Oncogene - 10 Jan 2013
Trerotola M, Cantanelli P, Guerra E, Tripaldi R, Aloisi A L, Bonasera V, Lattanzio R, de Lange R, Weidle U H, Piantelli M, Alberti S
Abstract excerpt
Trop-2 is a calcium signal transducer that is associated with transformed cell growth in experimental systems. However, its role in human cancer remains essentially unknown. In this study, we profiled Trop-2 expression in normal human tissues at the mRNA and protein levels. We then systematically compared Trop-2 mRNA and protein levels in tumours with their tissues of origin. We find that Trop-2 expression is...
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