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Article

AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 Inhibition

21 Dec 2013

Abstract excerpt

UNLABELLED: Acquired tamoxifen resistance develops in the majority of hormone-responsive breast cancers and frequently involves overexpression of the PI3K/AKT axis. Here, breast cancer cells with elevated endogenous AKT or overexpression of activated AKT exhibited tamoxifen-stimulated cell proliferation and enhanced cell motility. To gain mechanistic insight on AKT-induced endocrine resistance, gene expression...

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PMID: 24362250
DOI: 10.1158/1541-7786.mcr-13-0219

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