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AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

13 Mar 2017

Abstract excerpt

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines and showed that AKT1 promoted cell proliferation, through S6 and cyclin D1 upregulation, but it inhibited cell migration and invasion through β1-integrin and focal...

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PMID: 28287129
DOI: 10.1038/srep44244

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