Article

A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signaling

2020-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Intercellular mechanisms by which the stromal microenvironment contributes to solid tumor progression and targeted therapy resistance remain poorly understood, presenting significant clinical hurdles. PEAK1 (Pseudopodium-Enriched Atypical Kinase One) is an actin cytoskeleton- and focal adhesion-associated pseudokinase that promotes cell state plasticity and cancer metastasis by mediating growth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 730e5323-6fb6-5c6c-a2db-2b578466c5f3
DOI: 10.1101/2020.05.15.098772

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signalingDOI 10.1101/2020.05.15.098772Read

JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast CancerSemantic proximity Read

Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancerSemantic proximity Read

THAP7-AS1 recruits the SWI/SNF to activate EGFR-ELK1 signaling and induce crosstalk between tumor-associated macrophages and breast cancer cellsSemantic proximity Read

The PIK3CA gene and its pivotal role in tumor tropism of triple-negative breast cancerSemantic proximity Read

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumorsSemantic proximity Read

eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell GrowthSemantic proximity Read

IRAK2 contributes to triple-negative breast cancer growth via NF-κB, ERK and stress-related signaling pathwaysSemantic proximity Read

S1P/S1PR1 signaling couples mitochondrial Ca²⁺-dependent cytoskeletal remodeling to IL-6/IL-33-driven macrophage polarization in breast cancerSemantic proximity Read

IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancerSemantic proximity Read

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteinsSemantic proximity Read

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancerSemantic proximity Read

Pathway activity profiling of growth factor receptor network and stemness pathways differentiates metaplastic breast cancer histological subtypesSemantic proximity Read