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Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2

7 Mar 2006

Abstract excerpt

Akt1 is frequently up-regulated in human tumors and has been shown to accelerate cell proliferation and to suppress programmed cell death; consequently, inhibition of the activity of Akt1 has been seen as an attractive target for therapeutic intervention. Paradoxically, hyperactivation of the Akt1 oncogene can also prevent the invasive behavior that underlies progression to metastasis. Here we show that...

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PMID: 16537497
DOI: 10.1073/pnas.0511342103

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