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Article

Synergistic Effects of APOE and CLU May Increase the Risk of Alzheimer's Disease: Acceleration of Atrophy in the Volumes and Shapes of the Hippocampus and Amygdala.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

An Na, Fu Yu, Shi Jie, Guo Han-Ning, Yang Zheng-Wu, Li Yong-Chao, Li Shan, Wang Yin, Yao Zhi-Jun, Hu Bin

Abstract excerpt

BACKGROUND: The volume loss of the hippocampus and amygdala in non-demented individuals has been reported to increase the risk of developing Alzheimer's disease (AD). Many neuroimaging genetics studies mainly focused on the individual effects of APOE and CLU on neuroimaging to understand their neural mechanisms, whereas their synergistic effects have been rarely studied. OBJECTIVE: To assess whether APOE and CLU...

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PMID: 33682707
DOI: 10.3233/JAD-201162

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