Article
Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score.
The Journal of investigative dermatology - 1 Mar 2016
Kypreou Katerina P, Stefanaki Irene, Antonopoulou Kyriaki, Karagianni Fani, Ntritsos Georgios, Zaras Alexios, Nikolaou Vasiliki, Kalfa Iro, Chasapi Vasiliki, Polydorou Dorothea, Gogas Helen, Spyrou George M, Bertram Lars, Lill Christina M, Ioannidis John P A, Antoniou Christina, Evangelou Evangelos, Stratigos Alexander I
Abstract excerpt
Many single nucleotide polymorphisms (SNPs) have been described as putative risk factors for melanoma. The aim of our study was to validate the most prominent genetic risk loci in an independent Greek melanoma case-control dataset and to assess their cumulative effect solely or combined with established phenotypic risk factors on individualized risk prediction. We genotyped 59 SNPs in 800 patients and 800...
Topics
- Analysis of Variance
- Cross-Sectional Studies
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Loci
- Genome-Wide Association Study
- Genotype
- Greece
- Humans