Article
Joint effect of multiple common SNPs predicts melanoma susceptibility.
PloS one - 1 Jan 2013
Fang Shenying, Han Jiali, Zhang Mingfeng, Wang Li-e, Wei Qingyi, Amos Christopher I, Lee Jeffrey E
Abstract excerpt
Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional phenotypic model. We analyzed 11 SNPs that were associated with melanoma risk in previous studies and were genotyped in MD Anderson Cancer Center (MDACC) and...
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