Article
Melanoma risk prediction using a multilocus genetic risk score in the Women's Health Initiative cohort.
Journal of the American Academy of Dermatology - 1 Jul 2018
Cho Hyunje G, Ransohoff Katherine J, Yang Lingyao, Hedlin Haley, Assimes Themistocles, Han Jiali, Stefanick Marcia, Tang Jean Y, Sarin Kavita Y
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) associated with melanoma have been identified though genome-wide association studies. However, the combined impact of these SNPs on melanoma development remains unclear, particularly in postmenopausal women who carry a lower melanoma risk. OBJECTIVE: We examine the contribution of a combined polygenic risk score on melanoma development in postmenopausal women....
Topics
- Age Distribution
- Aged
- Cohort Studies
- Databases, Factual
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Logistic Models
- Melanoma