Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies.

doi:10.1016/j.jid.2018.05.023

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Article

Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies.

The Journal of investigative dermatology - 1 Dec 2018

Cust Anne E, Drummond Martin, Kanetsky Peter A, Goldstein Alisa M, Barrett Jennifer H, MacGregor Stuart, Law Matthew H, Iles Mark M, Bui Minh, Hopper John L, Brossard Myriam, Demenais Florence, Taylor John C, Hoggart Clive, Brown Kevin M, Landi Maria Teresa, Newton-Bishop Julia A, Mann Graham J, Bishop D Timothy

Abstract excerpt

It is unclear to what degree genomic and traditional (phenotypic and environmental) risk factors overlap in their prediction of melanoma risk. We evaluated the incremental contribution of common genomic variants (in pigmentation, nevus, and other pathways) and their overlap with traditional risk factors, using data from two population-based case-control studies from Australia (n = 1,035) and the United Kingdom...

Topics

Adolescent
Adult
Aged
Alleles
Australia
Ethnicity
Female
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Melanoma

Middle Aged

Pathology, Molecular

Polymorphism, Genetic

Population Groups

Prognosis

Risk Assessment

Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29890168
DOI: 10.1016/j.jid.2018.05.023
PMCID: PMC6249137

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