Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma.

doi:10.1093/hmg/ddy282

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Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma.

Human molecular genetics - 1 Dec 2018

Gu Fangyi, Chen Ting-Huei, Pfeiffer Ruth M, Fargnoli Maria Concetta, Calista Donato, Ghiorzo Paola, Peris Ketty, Puig Susana, Menin Chiara, De Nicolo Arcangela, Rodolfo Monica, Pellegrini Cristina, Pastorino Lorenza, Evangelou Evangelos, Zhang Tongwu, Hua Xing, DellaValle Curt T, Timothy Bishop D, MacGregor Stuart, Iles Mark I, Law Matthew H, Cust Anne, Brown Kevin M, Stratigos Alexander J, Nagore Eduardo, Chanock Stephen, Shi Jianxin, Consortium Melanoma Meta-Analysis, Consortium MelaNostrum, Landi Maria Teresa

Abstract excerpt

Melanoma heritability is among the highest for cancer and single nucleotide polymorphisms (SNPs) contribute to it. To date, only SNPs that reached statistical significance in genome-wide association studies or few candidate SNPs have been included in melanoma risk prediction models. We compared four approaches for building polygenic risk scores (PRS) using 12 874 melanoma cases and 23 203 controls from Melanoma...

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PMID: 30060076
DOI: 10.1093/hmg/ddy282
PMCID: PMC6240742

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Source receipt: pubmed, retrieved 7 Sept 2026.

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