Article
Independent evaluation of melanoma polygenic risk scores in UK and Australian prospective cohorts.
The British journal of dermatology - 1 May 2022
Steinberg Julia, Iles Mark M, Lee Jin Yee, Wang Xiaochuan, Law Matthew H, Smit Amelia K, Nguyen-Dumont Tu, Giles Graham G, Southey Melissa C, Milne Roger L, Mann Graham J, Bishop D Timothy, MacInnis Robert J, Cust Anne E
Abstract excerpt
BACKGROUND: Previous studies suggest that polygenic risk scores (PRSs) may improve melanoma risk stratification. However, there has been limited independent validation of PRS-based risk prediction, particularly assessment of calibration (comparing predicted to observed risks). OBJECTIVES: To evaluate PRS-based melanoma risk prediction in prospective UK and Australian cohorts with European ancestry. METHODS: We...
Topics
- Australia
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Melanoma
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- Prospective Studies
- Risk Assessment
- Risk Factors
- United Kingdom