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Article

Genetics versus clinical risk scores for melanoma prediction.

The British journal of dermatology - 17 Jul 2026

Wang Huanwei, Ghajari Hadis, Jayasinghe G J M Shanika R, Seviiri Mathias, Gordon Scott D, Neale Rachel E, Pandeya Nirmala, Olsen Catherine M, MacGregor Stuart, Whiteman David C, Law Matthew H

Abstract excerpt

BACKGROUND: Cutaneous melanoma is a common cancer, for which risk stratification has been proposed to aid early detection. OBJECTIVES: To assess the performance of a polygenic risk score (PRS) in predicting the risk of invasive cutaneous melanoma, alone and combined with clinical risk factors. METHODS: The PRS was derived from the most recent genome-wide association study meta-analysis of cutaneous melanoma,...

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Identifiers

PMID: 41968088
DOI: 10.1093/bjd/ljag126
PMCID: PMC13378593

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