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Article

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila.

PloS one - 1 Jan 2016

Chang Ying-Ju, Zhou Lily, Binari Richard, Manoukian Armen, Mak Tak, McNeill Helen, Stambolic Vuk

Abstract excerpt

The insulin/IGF-1 signaling pathway mediates various physiological processes associated with human health. Components of this pathway are highly conserved throughout eukaryotic evolution. In Drosophila, the PTEN ortholog and its mammalian counterpart downregulate insulin/IGF signaling by antagonizing the PI3-kinase function. From a dominant loss-of-function genetic screen, we discovered that mutations of a...

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Identifiers

PMID: 27015411
DOI: 10.1371/journal.pone.0152259
PMCID: PMC4807833

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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