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Article

Ras promotes cell survival in Drosophila by downregulating hid expression.

Cell - 30 Oct 1998

Kurada P, White K

Abstract excerpt

Activation of Ras inhibits apoptosis during Drosophila development. Genetic evidence indicates that Ras antiapoptotic activity in the developing eye is regulated by the Drosophila EGF receptor and operates through the Raf/MAPK pathway. Decreased activity of this pathway enhances, and increased activity suppresses, apoptosis induced by ectopic expression of the cell death regulators reaper (rpr) and head...

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Source

Identifiers

PMID: 9814703
DOI: 10.1016/s0092-8674(00)81764-x

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras promotes cell survival in Drosophila by downregulating hid expression.PMID 9814703Read ↗

The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling.Semantic proximity Read ↗

Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.Semantic proximity Read ↗

reaper is required for neuroblast apoptosis during Drosophila development.Semantic proximity Read ↗

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.Semantic proximity Read ↗

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.Semantic proximity Read ↗

Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila.Semantic proximity Read ↗

Regulation of apoptosis of rbf mutant cells during Drosophila development.Semantic proximity Read ↗

The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.Semantic proximity Read ↗

Control of apoptosis by Drosophila DCAF12.Semantic proximity Read ↗

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.Semantic proximity Read ↗

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.Semantic proximity Read ↗

mir-11 limits the proapoptotic function of its host gene, dE2f1.Semantic proximity Read ↗

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