Article
Ras promotes cell survival in Drosophila by downregulating hid expression.
Cell - 30 Oct 1998
Kurada P, White K
Abstract excerpt
Activation of Ras inhibits apoptosis during Drosophila development. Genetic evidence indicates that Ras antiapoptotic activity in the developing eye is regulated by the Drosophila EGF receptor and operates through the Raf/MAPK pathway. Decreased activity of this pathway enhances, and increased ac...
Topics
- Alleles
- Animals
- Apoptosis
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Survival
- DNA-Binding Proteins
- Down-Regulation
- Drosophila Proteins
- Drosophila melanogaster
- ErbB Receptors
- Extracellular Signal-Regulated MAP Kinases
- Eye
- Eye Proteins
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Insect Proteins
- Models, Biological
- Mutation