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Article

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces.

Cancer research - 1 Jun 2016

Lloyd Mark C, Cunningham Jessica J, Bui Marilyn M, Gillies Robert J, Brown Joel S, Gatenby Robert A

Abstract excerpt

Spatial heterogeneity in tumors is generally thought to result from branching clonal evolution driven by random mutations that accumulate during tumor development. However, this concept rests on the implicit assumption that cancer cells never evolve to a fitness maximum because they can always acquire mutations that increase proliferative capacity. In this study, we investigated the validity of this assumption....

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Identifiers

PMID: 27009166
DOI: 10.1158/0008-5472.CAN-15-2962
PMCID: PMC5384728

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