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Article

Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.

Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2016

Shen Hua, McHale Cliona M, Haider Syed I, Jung Cham, Zhang Susie, Smith Martyn T, Zhang Luoping

Abstract excerpt

Though current functional genomic screening systems are useful for investigating human susceptibility to chemical toxicity, they have limitations. Well-established, high-throughput yeast mutant screens identify only evolutionarily conserved processes. RNA interference can be applied in human cells but is limited by incomplete gene knockout and off-target effects. Human haploid cell screening is advantageous as it...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27008852
DOI: 10.1093/toxsci/kfw032
PMCID: PMC4914802

Genes

CTC1
FCRLA
GOT1
LYRM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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