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Mammalian Chemical Genomics towards Identifying Targets and Elucidating Modes-of-Action of Bioactive Compounds.

Chembiochem : a European journal of chemical biology - 5 Apr 2022

Matsumoto Ken, Yoshida Minoru

Abstract excerpt

The step of identifying target molecules and elucidating the mode of action of bioactive compounds is a major bottleneck for drug discovery from phenotypic screening. Genetic screening for genes that affect drug sensitivity or phenotypes of mammalian cultured cells is a powerful tool to obtain clues to their modes of action. Chemical genomic screening systems for comprehensively identifying such genes or genetic...

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PMID: 34813140
DOI: 10.1002/cbic.202100561

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