Article
Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population.
Diabetologia - 1 Jul 2016
Yan Jing, Peng Danfeng, Jiang Feng, Zhang Rong, Chen Miao, Wang Tao, Yan Dandan, Wang Shiyun, Hou Xuhong, Bao Yuqian, Hu Cheng, Jia Weiping
Abstract excerpt
AIMS/HYPOTHESIS: We aimed to evaluate the combined effects of type 2 diabetes risk variants on predicting deterioration of blood glucose and progression of beta cell function and insulin sensitivity in a 9 year prospective cohort from the Chinese population. METHODS: We constructed a weighted genetic risk score (GRS) model based on 40 variants associated with type 2 diabetes validated in an established...
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