Article
Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.
Diabetes - 1 Apr 2011
Hivert Marie-France, Jablonski Kathleen A, Perreault Leigh, Saxena Richa, McAteer Jarred B, Franks Paul W, Hamman Richard F, Kahn Steven E, Haffner Steven, Meigs James B, Altshuler David, Knowler William C, Florez Jose C
Abstract excerpt
OBJECTIVE: Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested if a GRS based on an updated list of 34 type 2 diabetes-associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes Prevention Program...
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