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Article

Association of Polygenic Variants with Type 2 Diabetes Risk and Their Interaction with Lifestyles in Asians.

Nutrients - 6 Aug 2022

Hur Haeng Jeon, Yang Hye Jeong, Kim Min Jung, Lee Kyun-Hee, Kim Myung-Sunny, Park Sunmin

Abstract excerpt

Over the last several decades, there has been a considerable growth in type 2 diabetes (T2DM) in Asians. A pathophysiological mechanism in Asian T2DM is closely linked to low insulin secretion, β-cell mass, and inability to compensate for insulin resistance. We hypothesized that genetic variants associated with lower β-cell mass and function and their combination with unhealthy lifestyle factors significantly...

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Asian People
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Genome-Wide Association Study
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 35956399
DOI: 10.3390/nu14153222
PMCID: PMC9370736

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