Article
Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals.
Diabetologia - 1 Sept 2014
Zhu Jingwen, Zong Geng, Lu Ling, Gan Wei, Ji Linong, Hu Renming, Ye Xingwang, Sun Liang, Loos Ruth J F, Li Huaixing, Lin Xu
Abstract excerpt
AIMS/HYPOTHESIS: Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. METHODS: In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing alleles of these variants were tested for associations with type 2 diabetes and related glycaemic...
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