Article
Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals.
Diabetes care - 1 Aug 2012
Iwata Minoru, Maeda Shiro, Kamura Yutaka, Takano Atsuko, Kato Hiromi, Murakami Shihou, Higuchi Kiyohiro, Takahashi Atsushi, Fujita Hayato, Hara Kazuo, Kadowaki Takashi, Tobe Kazuyuki
Abstract excerpt
OBJECTIVE: We evaluated the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes. RESEARCH DESIGN AND METHODS: We analyzed 14 SNPs at HHEX, CDKAL1, CDKN2B, SLC30A8, KCNJ11, IGF2BP2, PPARG, TCF7L2, FTO, KCNQ1, IRS-1, GCKR, UBE2E2, and C2CD4A/B in 1,487 Japanese individuals (724 patients with type 2 diabetes and 763 control subjects). A GRS was calculated...
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