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Article

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Nature communications - 23 Mar 2016

Li Xiujuan, Padhan Narendra, Sjöström Elisabet O, Roche Francis P, Testini Chiara, Honkura Naoki, Sáinz-Jaspeado Miguel, Gordon Emma, Bentley Katie, Philippides Andrew, Tolmachev Vladimir, Dejana Elisabetta, Stan Radu V, Vestweber Dietmar, Ballmer-Hofer Kurt, Betsholtz Christer, Pietras Kristian, Jansson Leif, Claesson-Welsh Lena

Abstract excerpt

The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adherens junctions and...

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Identifiers

PMID: 27005951
DOI: 10.1038/ncomms11017
PMCID: PMC4814575

Genes

VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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