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Regulation of lymphatic-blood vessel separation by endothelial Rac1

11 Nov 2009

Abstract excerpt

Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown. Here, we deleted endothelial Rac1 in mice (Tie1-Cre(+);Rac1(fl/fl)) and revealed, unexpectedly, that whereas blood vessel morphology appeared normal,...

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PMID: 19906871
DOI: 10.1242/dev.035014

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