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Efficient fine-tuning of endothelial gene expression by a single Tyrosine to Phenylalanine point mutation in the <i>VE-cadherin</i> gene

2024-04-22

Abstract excerpt

Cancer and inflammation are associated with vascular diseases that affect endothelial cells (ECs) and alter gene expression. We aimed at understanding whether the site Y 685 in the cytoplasmic domain of VE-cadherin triggers epigenetic programming in vivo . Using our knock-in mice carrying the Y 685 F VE-cadherin mutation, RNA sequencing from lung ECs identified 884 differentially expressed genes (DEG) involved...

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Literature Corpus work
305eff9f-4de8-5123-a7f1-af1890e5da11
DOI
10.1101/2024.04.17.589974
Open publication

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Efficient fine-tuning of endothelial gene expression by a single Tyrosine to Phenylalanine point mutation in the <i>VE-cadherin</i> geneDOI 10.1101/2024.04.17.589974
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