Article
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 2008
Yuan Tina L, Choi Hak Soo, Matsui Aya, Benes Cyril, Lifshits Eugene, Luo Ji, Frangioni John V, Cantley Lewis C
Abstract excerpt
PI3K is important in the regulation of growth, proliferation, and survival of tumor cells. We show that class 1A PI3K is also critical in the tumor microenvironment by regulating the integrity of the tumor vasculature. Using Tie2Cre-mediated deletion of the PI3K regulatory subunits (p85alpha, p55alpha, p50alpha, and p85beta), we generated mice with endothelial cell-specific loss of class 1A PI3K. Complete loss of...
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