Article
Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus.
Cardiovascular diabetology - 22 Mar 2016
Zhang Dingyu, Zhang Xiaolin, Liu Dan, Liu Tengfei, Cai Wenzhi, Yan Chenghui, Han Yaling
Abstract excerpt
BACKGROUND: The mechanisms leading to the high on-treatment platelet reactivity in diabetes patients are not fully elucidated. The genetic factors may be associated with the diminished antiplatelet efficacy of dual antiplatelet therapy. We investigated the possible association between insulin receptor substrate-1 (IRS-1) polymorphisms and high platelet reactivity in coronary artery disease (CAD) patients with...
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