Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.

doi:10.1016/j.jacc.2011.02.040

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Article

Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.

Journal of the American College of Cardiology - 28 Jun 2011

Angiolillo Dominick J, Bernardo Esther, Zanoni Martina, Vivas David, Capranzano Piera, Malerba Giovanni, Capodanno Davide, Prandini Paola, Pasquali Alessandra, Trabetti Elisabetta, Sabaté Manel, Jimenez-Quevedo Pilar, Ferreiro Jose L, Ueno Masafumi, Bass Theodore A, Pignatti Pier Franco, Fernandez-Ortiz Antonio, Macaya Carlos

Abstract excerpt

OBJECTIVES: The aim of this study was to assess the association between genetic variants of the insulin receptor substrate (IRS)-1 gene, platelet function, and long-term outcomes in patients with type 2 diabetes mellitus (DM) and stable coronary artery disease while on aspirin and clopidogrel therapy. BACKGROUND: The effects of pharmacogenetic determinants on platelet function and cardiovascular outcomes in type...

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PMID: 21700086
DOI: 10.1016/j.jacc.2011.02.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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