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Article

Impact of Insulin Receptor Substrate-1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention.

Journal of the American Heart Association - 16 Aug 2022

Zong Jiaxin, Tang Yingdan, Wang Tong, Ullah Inam, Xu Ke, Wang Jing, Chen Pengsheng, Chen Zengguang, Zhu Tiantian, Chen Jun, Li Jimin, Wang Fei, Yang Lu, Fan Yuansheng, Shi Lu, Gong Xiaoxuan, Eikelboom John W, Zhao Yang, Li Chunjian

Abstract excerpt

Background Insulin receptor substrate-1 (IRS-1) rs956115 is associated with vascular risk in patients with coronary artery disease and concomitant diabetes. CYP2C19*2 (rs4244285) modulates clopidogrel response and predicts the outcome of coronary artery disease. This study was designed to explore the association between IRS-1, CYP2C19*2 genotypes, platelet reactivity, and 1-year outcome in patients with coronary...

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Identifiers

PMID: 35929455
DOI: 10.1161/JAHA.121.025058
PMCID: PMC9496289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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