Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma.

doi:10.1016/j.euroneuro.2016.03.003

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Article

Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2016

Lazary Judit, Eszlari Nora, Juhasz Gabriella, Bagdy Gyorgy

Abstract excerpt

Fatty acid amide hydrolase (FAAH) inhibitors are addressed for promising anxiolytics, but human studies on genetically reduced FAAH activity, stress and affective phenotypes are scarce. We investigated the effect of a functional polymorphism of FAAH (FAAH C385A or rs324420; low FAAH activity and high anandamide concentration are associated with the A allele) together with childhood adversity on the anxious and...

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Source

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Identifiers

PMID: 27005594
DOI: 10.1016/j.euroneuro.2016.03.003

Genes

FAAH

Variants

rs324420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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