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Article

Impact of Childhood Trauma Exposure, Genetic Variation in Endocannabinoid Signaling, and Anxiety on Frontolimbic Pathways in Children.

Cannabis and cannabinoid research - 1 Dec 2023

Marusak Hilary A, Evanski Julia, Desai Shreya, Rabinak Christine A

Abstract excerpt

Introduction: The endocannabinoid (eCB) system plays a key role in modulating brain development, including myelination processes. Recent studies link a common variant (C385A, rs324420) in the fatty acid amide hydrolase (FAAH) gene to higher circulating eCB levels, lower anxiety, and altered frontolimbic development. Frontolimbic pathways, which demonstrate a protracted maturational course across childhood and...

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Identifiers

PMID: 35944262
DOI: 10.1089/can.2022.0144
PMCID: PMC10714120

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