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On the role of epigenetic modifications of HPA axis in posttraumatic stress disorder and resilience

22 Jan 2025

Abstract excerpt

Stress is a fundamental adaptive response that invokes amygdala and hypothalamus-pituitary-adrenal (HPA) axis along with other brain regions. Extreme or chronic stress, however, can result in a multitude of neuropsychiatric disorders, including anxiety, paranoia, bipolar disorder (BP), major depressive disorder (MDD), and posttraumatic stress disorder (PTSD). Despite widespread exposure to trauma (70.4%), the...

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PMID: 39842807
DOI: 10.1152/jn.00345.2024

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