Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype.

doi:10.1007/s00213-024-06717-3

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Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype.

Psychopharmacology - 1 Feb 2026

Marusak Hilary A, Ely Samantha L, Zundel Clara G, Gowatch Leah C, Shampine MacKenna, Carpenter Carmen, Tamimi Reem, Jaster Alaina M, Shakir Tehmina, May Len, deRoon-Cassini Terri A, Hillard Cecilia J

Abstract excerpt

BACKGROUND: The endocannabinoid system, which regulates fear- and anxiety-related behaviors, is dysregulated in adults with posttraumatic stress disorder (PTSD), as indicated by higher circulating anandamide (AEA) concentrations. The C385A (rs324420) polymorphism in the fatty acid amide hydrolase (FAAH) gene, which catabolizes AEA, is linked to higher AEA concentrations and greater PTSD symptoms in adults. Given...

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PMID: 39547971
DOI: 10.1007/s00213-024-06717-3

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FAAH

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