Article
Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence.
Behavioural brain research - 12 Apr 2024
Desai Shreya, Zundel Clara G, Evanski Julia M, Gowatch Leah C, Bhogal Amanpreet, Ely Samantha, Carpenter Carmen, Shampine MacKenna, O'Mara Emilie, Rabinak Christine A, Marusak Hilary A
Abstract excerpt
BACKGROUND: The endocannabinoid system modulates neural activity throughout the lifespan. In adults, neuroimaging studies link a common genetic variant in fatty acid amide hydrolase (FAAH C385A)-an enzyme that regulates endocannabinoid signaling-to reduced risk of anxiety and depression, and altered threat- and reward-related neural activity. However, limited research has investigated these associations during...
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